Patients taking estradiol on strict medical advice generally do not experience significant drowsiness. Estradiol is a steroidal estrogen with high content and activity, which helps the endometrium to proliferate and is one of the most important sex hormones. If the medication is not properly used there may be breast pain, weight gain, nausea, vomiting and other adverse reactions, and the body can tolerate all of the above adverse reactions, it is a normal phenomenon, will gradually disappear after stopping the medication, but generally does not produce drowsiness symptoms. If drowsiness occurs during the medication, the patient should go to the hospital to find out the reason and change the medication or stop the medication under the guidance of the doctor. Pay attention to observe their own physical condition during the medication, pay attention to drink more water, combine work and rest, and strictly follow the doctor’s instructions for medication.