The time window for stroke reperfusion therapy is usually within 4.5 hours of onset. Most strokes are due to cerebral vascular stenosis or occlusion, and patients mainly present with symptoms such as hemiplegia, unfavorable speech, slanting of the mouth, and coma. Stroke reperfusion is a rapid and effective technique to resolve cerebral ischemia, and the common clinical treatments are thrombolysis, embolization and stent implantation surgery, and bypass surgery. Since the time window for stroke reperfusion therapy is usually within 4.5 hours of onset. Therefore, if it is longer than 4.5 hours, it may cause reperfusion injury and the patient will have a significantly increased risk of bleeding, as well as inability to dissolve the embolus. In conclusion, the earlier the patient starts treatment, the better the outcome, regardless of the method of stroke reperfusion therapy.