Sore thigh muscles and inability to lift the feet may be caused by overwork or due to lumbar disc herniation, and the treatment includes physical therapy, medication and surgery. 1. Caused by over-exertion: Over-exertion of thigh muscles may cause muscle fatigue, leading to the above symptoms. Firstly, it is suggested that patients should reduce the amount of exercise, take more rest, and elevate the affected limbs to accelerate the venous return; secondly, they can choose to take a hot bath, massage, microwave therapy, etc. to accelerate the discharge of metabolites and relieve the fatigue of soft tissues. 2. Lumbar disc herniation: patients with mild lumbar protrusion can choose drugs such as methylcobalamin and vitamin B1 to nourish the nerves; they may also choose drugs such as mannitol and dexamethasone to reduce the nerve edema; if there are progressive symptoms of weakness in the thighs or lower limbs, and patients with ineffective conservative treatments, surgical interventions may be needed to relieve the symptoms of compression of the nerve roots. If the symptoms of thigh muscle pain and inability to lift the foot are not relieved, or accompanied by other symptoms, the patient should go to the hospital in a timely manner, to identify the cause and then give targeted treatment. The above medications should be used under the guidance of a doctor, avoid self-medication.