High anti-CCP antibody does not necessarily mean rheumatoid arthritis. Anti-CCP antibody, i.e. anti-cyclic citrullinated peptide antibody, should be less than 5RU/ml under normal conditions, and test results higher than this value are abnormal. Anti-CCP antibody is closely related to rheumatoid arthritis, and it has high sensitivity and specificity for the diagnosis of rheumatoid arthritis, and nowadays, the clinic often uses the combination of anti-CCP antibody and rheumatoid factor to make a clear diagnosis of rheumatoid arthritis. High anti-CCP antibody does not confirm the diagnosis of rheumatoid arthritis. The diagnosis of rheumatoid arthritis needs to be analyzed in conjunction with the patient’s clinical symptoms, medical history, physical signs and X-rays, blood sedimentation, and other ancillary results. Anti-CCP antibody test results should be interpreted by a professional physician, and it is recommended that patients with high anti-CCP antibody should consult with the rheumatology and immunology department of a regular hospital in time to avoid delaying their condition.