Osteomyelitis without systemic symptoms may be the early stage of acute osteomyelitis or chronic osteomyelitis, and the treatment mainly includes medication and surgery, etc. The treatment of osteomyelitis without systemic symptoms may be the early stage of acute osteomyelitis or chronic osteomyelitis. 1. Drug therapy: it is suitable for patients with early stage of acute osteomyelitis, at this time, the lesion is more limited, antibiotic treatment is an important means of treatment, need to use a full course of treatment, full dose of broad-spectrum antibiotics or combination of drugs, commonly used medicines, such as cefoperazone, ceftriaxone, meropenem and so on. Patients with obvious edema can be put on a drip of mannitol, hepatic saponin sodium and other drugs to reduce swelling. 2. Surgery: for chronic osteomyelitis or acute osteomyelitis patients with poor results of conservative treatment, chronic osteomyelitis due to the longer course of the disease, the sensitivity to antibiotics is poor or there has been antibiotic-resistant, most need to carry out surgical treatment. Surgical procedures include debridement and decompression, dead bone removal, and osteotomy. The specific type of surgery needs to be decided by the doctor after a comprehensive evaluation based on the patient’s original disease. For the same disease, patients with different physical conditions and different stages of the disease have different treatment methods, and should be standardized under the guidance of the doctor. The above medication should be administered under the guidance of a doctor to avoid blind use of medication.