Significant swelling of the left ankle is seen in the following conditions. First, ligament or local phlebitis caused by chronic strain, which manifests as swelling and positive acupressure marks. X-rays can also indicate local bone degeneration or hyperplasia, which can be improved by oral glucosamine sulfate, as well as local heat application and elevation of the limb. Second, some patients are due to venous blood system diseases, blood stagnation and poor return, commonly varicose veins in the lower extremities, and even local thrombophlebitis may also form. Patients also experience local swelling and pain, and in severe cases, ulcers in the foot and boot area and skin breakdown secondary to infection, which should be treated systematically to strip the superficial veins.