Doctor, our village doctor said: diabetic patients take Western medicine is not good, hurt the liver and kidneys …… Doctor, my village’s old Wang said: insulin is not good, easy to become addicted …… Doctor, my village’s old Li said: take Chinese medicine is best …… Doctor, my village’s …… Walking in the ward every day, listening to the patients talk about the journey they once took to see the doctor, listening to them talk about the confusion in their hearts, with bitterness, remorse, sympathy, and emotion, my heart is heavy: there is a long way to go in diabetes treatment education. Some people refused the standardized glucose-lowering treatment, which led to blindness and amputation; some people applied Chinese medicine to lower glucose treatment which led to kidney failure …… To sum up: diabetic patients choose western medicine according to their condition; insulin is not addictive, apply insulin according to your condition, click on the related article to understand (doctor, don’t talk to me about insulin and insulin pump, I’m afraid); never listen to friends or wandering doctors or radio broadcast recommendations, take Chinese medicine or health care products to lower sugar indiscriminately, remember remember remember. Today, only talk about our most familiar glucose-lowering drugs – metformin. 1, metformin does not hurt the liver: it does not metabolize through the liver, but in its original form through the kidney excretion, so no liver toxicity. But the liver function will be severely impaired will limit the clearance of lactic acid, so avoid using it when the transaminase is more than 3 times the normal upper limit. 2, metformin does not hurt the kidney: the drug is excreted in its original form through the kidneys, no nephrotoxicity. Mild to moderate renal insufficiency can be used metformin, the criteria is GFR <45 mL/(min-1.73m2) is prohibited in patients. Patients who are taking metformin, when but GFR between 45-59ml/(min-1.73m2) do not need to stop the drug, can reduce the dose to continue to use. 3.Not recommended for children under 10 years old: Metformin can be used in children or adolescents with T2DM aged 10 years and above, and the maximum dose should not exceed 2000mg/d. 4.It is not recommended for pregnant women. 5, older patients older than 65 years old, can be applied, need to review renal function regularly (3-6 months). It can also be applied to the elderly who are older than 80 years old, need to start with small dose. 6.Metformin alone does not cause hypoglycemia, if combined with insulin or insulin promoter can increase the risk of hypoglycemia. 7.Adverse reactions are gastrointestinal reactions, which can be reduced by starting with small doses and taking orally after meals. 8.Before the contrast examination, the renal function is normal, you can stop metformin; abnormal renal function, stop metformin 48 hours before the contrast examination. 9.After the contrast examination, it is recommended to stop metformin for 72 hours and recheck the normal renal function before application. 10.Metformin can reduce body weight and is a priority drug for overweight or obese diabetic patients. 11, the latest research shows: metformin can slow down the role of atherosclerosis; metformin can improve metabolic disorders in patients with polycystic ovary syndrome; metformin may slow down aging; metformin has the role of reducing tumor morbidity and mortality (of course, most of these studies are foreign, need further research to confirm) Metformin is not a miracle drug ah? Not necessarily a miracle drug, but definitely a good drug, is cost-effective drugs, the people can afford to eat, the exact effect of lowering sugar, low risk of hypoglycemia, how to apply need to consult a professional doctor.