Hepatic polycystic disease is defined as multiple cysts of the liver, clinically referred to as polycystic liver; polycystic liver belongs to the congenital chromosomal dominant genetic disease, which often manifests hepatomegaly and multiple diffuse damage of the liver. Polycystic liver belongs to the congenital chromosomal dominant genetic disease, in which the cysts mainly originate from abnormal changes in the biliary tract, often accompanied by multiple renal cysts. The clinical manifestations of polycystic liver usually have no abnormal symptoms in the early stage, or only the symptom of liver enlargement. As the disease progresses, the liver cysts grow gradually and can affect liver function, causing multiple diffuse damage to the liver. When liver function is impaired, symptoms such as right upper abdominal pain, abdominal distension, loss of appetite, nausea and vomiting can occur. Polycystic liver can be diagnosed by imaging examination, and also need to be combined with laboratory tests to observe and understand the liver function; polycystic liver can have certain complications, such as jaundice, infection, bleeding, etc., so it is necessary to review the specific degree of development of the cysts on a regular basis. When there are no clinical symptoms in the early stage of polycystic liver, it can be followed up regularly and reviewed once every 6~12 months; if polycystic liver affects liver function and is accompanied by abnormal clinical symptoms, surgical treatment is needed; commonly used surgical methods include puncture aspiration and sclerotherapy, wide open or regular lobectomy, transhepatic open surgery, liver transplantation and so on. Multiple cystic lesions of the liver need to go to the hospital in time to check the specific degree of development and treatment, so as not to delay the condition.