The side effects of tetanus injection are mainly manifested in the following aspects: firstly, anaphylactic shock, which often occurs suddenly in minutes to tens of minutes during or after the injection, and the patient manifests irritability, pale or flushed face, tightness in the chest, shortness of breath, cold sweating, nausea, abdominal pain, fine pulse, drop in blood pressure, and even delirium and hypomania; secondly, the patient is prone to urticaria, fever, and lymphatic enlargement, localized swelling, and occasionally proteinuria, vomiting, arthralgia and other symptoms, the injection site may also appear erythema, itching and edema. The above adverse reactions are all the adverse reactions of tetanus antitoxin routinely applied in hospitals, and there are basically no serious adverse reactions if tetanus immunoglobulin is applied.