Pharyngeal syndrome refers to a condition in which the patient has sensory symptoms such as foreign body, obstruction or irritation in the pharynx. Due to the obvious symptoms, and often no organic lesions, sometimes easy to be ignored. In severe cases, the painful manifestations and consequences of this disease are no less than some organic lesions. As early as the ancient times in China, this disease has been recorded in the “Treatise on the Origin of Diseases” written by Chao Yuanfang of the Sui Dynasty in the sixth century AD, describing its symptoms as plum kernels blocking the throat, so Chinese medicine called “plum kernel gas”. There is not much research and discussion on this disease in foreign countries, and there is a lack of unified understanding of the causes, pathogenesis, clinical features, diagnosis and treatment of this disease. It is easy to be misdiagnosed as “chronic pharyngitis”, and the long-term ineffectiveness of medication adds to the burden of patients’ minds and becomes a “persistent” disease that cannot be cured. After the clinical investigation of patients in our center, we found that gastroesophageal reflux is an important cause of this disease, but because most doctors in China still have limited understanding of the extraesophageal aspects of GERD, it often leads to misdiagnosis. High reflux of gastric contents into the pharynx creates long-term and continuous irritation to the pharynx, which increases the sensitivity of the pharynx and causes pharyngeal xerostomia. For the treatment of this disease, the primary disease should be treated first. 1, general therapy, that is, adjuvant therapy: ① anti-reflux diet, high protein, low fat; ② keep an upright position after meals; ③ elevate the head of the bed, avoid full meals or drinking before bed; ④ avoid taking pro-reflux drugs, such as Valium, theophylline, progesterone, dopamine; ⑤ quit smoking and alcohol, strong tea and coffee as much as possible to control. 2, drug therapy: the more serious cases, when the general treatment is not effective, can be used for drug therapy, including antacids, prokinetic drugs, mucosal protective agents. Ranitidine, omeprazole, esomeprazole, etc. can effectively reduce the gastric pH, reduce nighttime gastric acid secretion; morpholine for gastric motility, can promote gastrointestinal emptying, improve the lower esophageal sphincter pressure, increase the anti-reflux effect; erythromycin is the only antibiotic gastric motility receptor agonist, has a significant gastrointestinal motility effect, can improve the lower esophageal sphincter pressure, and confirmed to reduce asthma bronchial high It is used for the treatment of chronic airway infectious diseases, and has good efficacy. 3, surgical treatment: gastroesophageal reflux serious, drug treatment is ineffective or unwilling to take long-term medication, can consider surgical treatment. At present, more successful anti-reflux surgery mainly includes: micro radiofrequency therapy and laparoscopic fundoplication. Based on the results of the patient’s gastroscopy, acid measurement and pressure measurement, we will develop a relatively reasonable and sound treatment plan for the patient. These two treatment options have the effect of compensating each other and complementing each other.