Pharyngeal reflux disease (LPRS) is a disease that began to receive attention abroad in the 1980s. The pathogenesis of reflux disease has been studied more in the past for gastroesophageal reflux. There are no definite statistical results on laryngopharyngeal reflux disease. A study in the United States estimated that 10% of patients coming to the ear, nose and throat clinic had signs and symptoms of reflux laryngopharyngeal reflux disease is a common clinical condition, which was not sufficiently recognized in the past, resulting in unnecessary surgery or inappropriate treatment for most patients. Pharyngeal reflux is laryngopharyngeal reflux is the reflux of gastric contents into the upper esophageal sphincter above the nasopharynx, oropharynx, laryngopharynx and larynx. 24-hour dual-probe pH monitoring is used as the gold standard for diagnosing LPRD. Clinical manifestations:Articulatory fatigue or hoarseness: the most common, 92%-100%, chronic throat clearing, pharyngeal sputum, chronic cough, pharyngeal foreign body sensation, nasal reflux, asthma, dysphagia, more than half of patients deny heartburn symptoms, and a few patients may also present with serious conditions such as laryngospasm, laryngeal stenosis, Renk’s gap edema, laryngeal contact granuloma, precancerous lesions, and laryngeal cancer. Common diseases: chronic pharyngitis, chronic laryngitis, laryngeal contact granuloma, paroxysmal laryngospasm, laryngeal gap edema, vocal cord leukoplakia, acoustic laryngeal cancer, chronic cough, asthma, etc. Therefore, it is especially important to diagnose and treat patients with laryngeal reflux disease in a timely manner.