Hand and foot skin ulcers that do not heal for a long time may be caused by malignant tumors, long-term pressure, repeated infections or diabetes, etc. It is recommended that the patients should be treated by drugs or surgery under the guidance of doctors. 1. Skin cancer: when skin cancer occurs in hands and feet, it can lead to skin ulcers that do not heal for a long time, and patients can use surgery to remove the cancerous skin to improve. 2. Long-term pressure and friction: when the skin of hands and feet is subjected to pressure and friction for a long time, it can also lead to prolonged treatment. Then patients should minimize the friction and squeeze the skin of hands and feet, and actively carry out trauma treatment. 3. Repeated infections: When the skin of the hands and feet are repeatedly infected, it can also lead to prolonged treatment. Antibiotic drugs can be used externally, such as mupirocin ointment, fusidic acid ointment and so on. 4. Diabetes: For some patients with diabetes, it is also easy to cause the skin of the hands and feet do not heal. Then patients need to control blood sugar at a stable level, such as the use of insulin or metformin and other hypoglycemic drugs, and then actively carry out debridement treatment. For patients with long-lasting hand and foot ulcers, it is recommended to go to a regular hospital for examination and standardized treatment under the guidance of a professional doctor.