Which has more side effects, cephalosporins or azithromycin, should be judged according to the disease being treated. Both cephalosporins and azithromycin are antibiotics, but the antibacterial spectrum of these two drugs is not exactly the same. If it is used for the infection of mycoplasma, Azithromycin performance treatment should be chosen, when the use of cephalosporins is more harmful to the human body. If there is a clear Xu Jun infection, treatment with cephalosporins is more effective when mycoplasma infection is excluded. When using these two drugs for treatment, patients should apply them under the guidance of a doctor.