Nails with uneven holes may be caused by nail malnutrition, may also be caused by nail fungus, and may be the cause of psoriasis nails, can be under the guidance of the doctor through oral medication or application of medication way of treatment. 1. Nail malnutrition: micronutrient deficiencies can lead to small, uneven holes in the nails. According to the test results, appropriate supplementation of the required micronutrient deficiencies, usually eat more food with high calcium and iron content. 2. Ringworm of the nail: it may be due to fungi such as dermatophytes and yeast attacking the nails, leading to breakage of the nail plate, thus causing the patient to have uneven holes in the nails. You can take itraconazole capsules, terbinafine hydrochloride tablets and other drugs for treatment. 3. Psoriasis nails: Nail changes accompanying psoriasis require active treatment of psoriasis, and after psoriasis is under control, the unevenness of the nails will also improve. When the symptoms of uneven small holes in the nails appear, it is necessary to consult a doctor in time, so as to avoid the worsening of the condition due to delayed treatment. The above medications should be used under the supervision of a doctor.