White wine plus cephalosporin may produce a disulfiram-like reaction, which can cause anaphylaxis or even death in severe cases. Disulfiram-like reaction refers to cephalosporin, metronidazole, nitroimidazole and some sulfonamides have disulfiram-like effect, which can inhibit the enzyme of acetaldehyde dehydrogenase in the human body. If you drink alcohol while using the drug, it will lead to the accumulation of acetaldehyde in the body, resulting in a variety of toxic reactions, including facial flushing, violent pulsation of blood vessels in the head and neck, conjunctival congestion, blurred vision. There are also symptoms such as skin rash, nausea, vomiting, panic, rapid heart rate, etc. In severe cases, it may lead to respiratory distress and anaphylactic shock, and untimely treatment may lead to death. Generally speaking, mild cases can be relieved on their own, while more severe cases need oxygen and symptomatic treatment. During the application of cephalosporin antibiotics for anti-infection treatment, as well as within 7 days after the discontinuation of the drug should not be able to drink alcohol, including white wine, red wine, yellow wine, etc., as well as drinks containing alcohol, food, such as alcohol chocolate, mash food, should be avoided at the same time. Otherwise, it may lead to disulfiram-like reaction, and the symptoms usually appear about 5 to 40 minutes after exposure to alcohol. In patients with sensitive bodies, a disulfiram-like reaction can occur after consuming a small amount of alcohol.