Taking targeted drugs can also produce drug resistance, and after the emergence of drug resistance, you need to choose to change drugs, radiotherapy or immunotherapy to treat the disease under the professional evaluation of doctors. Resistance to targeted drugs means that the tumor cells become resistant to the drugs, resulting in a significant decrease in the therapeutic effect of the drugs and the inability to play the normal role of the drugs. After drug resistance occurs, the targeted drug can be changed under the guidance of the doctor, and the commonly used targeted drugs in the clinic include gefitinib, trastuzumab, bevacizumab, etc. The tumor cells can also be treated with radiotherapy or immunotherapy, and the tumor cells can be treated with immunotherapy. You can also choose radiotherapy to treat the disease, common chemotherapy drugs are cyclophosphamide, paclitaxel, methotrexate and so on. In addition to replacement drugs and radiotherapy, immunotherapy can also control the malignant proliferation of the tumor well. Therefore, when resistance to targeted drugs appears, it is recommended to go to the hospital and receive standardized treatment under the guidance of professional doctors.