(Disclaimer: This article is only for scientific purposes. To protect the patient’s privacy, the relevant information in the following content has been processed.) Abstract: The patient is a 47-year-old woman whose husband died seven months ago, and the patient often can’t find her way home, and she often wanders around in front of her house and at street entrances, even though she thinks about it repeatedly. At first, her family thought it was due to mental trauma, but her symptoms gradually worsened, so she came to the hospital. She was diagnosed with vascular dementia and disorientation, and was given medication to stabilize her condition and reduce her symptoms. Basic information] Female, 47 years old [Type of disease] vascular dementia, disorientation disorder [Hospital] Shandong Third Hospital [Time of consultation] January 2019 [Treatment plan] medication (donepezil hydrochloride tablets + cytarabine sodium capsule + ginkgo biloba leaf extract tablets + aspirin enteric-coated tablets) [Period of treatment] hospitalization for 14 days, outpatient follow-up after 1 month [Treatment effect] condition stabilized, symptoms reduced. I. Initial Consultation The patient was brought to the clinic by her daughter, who was living at home alone because she was working abroad. Neighbors reported that the patient often could not find her way home and wandered around in front of her house at the intersection, and her daughter was very worried, so she came to the hospital for consultation. The family described that after the death of her husband 7 months ago, the patient had been in a depressed state. At first, it was considered to be caused by mental trauma, and it was thought that the patient would get better after a period of time, but the symptoms of the patient’s inability to find her way back home became more and more serious. After a brief understanding of his condition, a neurological examination revealed no obvious abnormalities, and a cognitive function assessment suggested that he was suffering from disorientation, and hospitalization was recommended to improve the relevant examinations and clarify the diagnosis. Preliminary diagnosis of cognitive dysfunction-disorientation disorder was made in the outpatient clinic. The patient was admitted to the hospital to improve a series of relevant examinations, cranial brain magnetic resonance and angiography suggests: multiple ischemic infarct foci in the brain, cerebrovascular atherosclerosis and localized obvious stenosis. Blood routine, liver and kidney function, ionization, blood lipid, blood glucose, the results are as follows: cardiac enzyme suggests high blood glucose, high blood lipid. Blood pressure was monitored to be high during hospitalization and was actively controlled in the usual way. The patient had recently suffered from prolonged sleep deprivation of about 5-6 hours per day; he had not taken any medication in the past; cognitive function assessment suggested moderate cognitive dysfunction; electroencephalogram did not show any significant abnormality; cerebrospinal fluid examination did not show any significant abnormality; and the combination of the results of the examination led to the diagnosis of vascular dementia and disorientation disorder. After admission, the patient was given medication, including donepezil hydrochloride tablets, cytarabine sodium capsules, ginkgo biloba extract tablets and aspirin enteric-coated tablets, to help improve brain metabolism, nourish brain cells and improve cognitive function. After the patient was admitted to the hospital, the relevant examinations were completed to exclude other diseases, and after the drugs to improve brain metabolism, nutritive brain cells, and cognitive function were given, the patient’s symptoms were significantly relieved, and he was discharged from the hospital on the 14th day of hospitalization, with instructions to his family members to do a good job of taking care of his family to avoid getting lost, and the outpatient follow up visit was made after 1 month, which revealed that the patient’s symptoms were relieved, and his family members said that the case of not being able to find the door of his house was significantly reduced. The patient’s early treatment with medication was effective, and should be followed up regularly in outpatient clinic to choose the appropriate medication and to confirm the need to adjust the medication. Fourth, precautions Patients through active and effective treatment, the number of wandering significantly reduced, truly happy for them. However, for patients with disorientation, daily supervision by family members is equally important. After being discharged from the hospital, it is recommended that family members choose specialized personnel to look after the patient and give medication at regular intervals for regular follow-up. Patients should exercise in general and participate in more cultural and sports activities to promote brain function in an active state. It is conducive to controlling the development of the disease. If symptoms occur, family members should do a good job of caretaking to avoid getting lost, and seek medical treatment in time to prevent aggravation of the disease. V. Personal perception Orientation disorder is a form of cognitive dysfunction, which refers to the decline in the patient’s ability to recognize and discriminate the orientation of a single stimulus. Patients with orientation disorder do not have obvious impairment of consciousness. It is seen in intracerebral lesions, such as organic psychosis, cerebral infarction cerebral hemorrhage sequelae, encephalitis, brain tumors, and cerebral metabolic diseases. For the elderly who have just lost their loved ones, their families should pay more psychological comfort and attention to them, be alert to the occurrence of diseases, and pay attention to some seemingly common symptoms and actively intervene. Regular checkups should be conducted in the hospital to understand the physical condition, and some high-risk factors leading to cardiovascular and cerebrovascular diseases should be controlled early to avoid the occurrence of the disease. If you are diagnosed with the same disease as the patient, you should also go to the hospital regularly to avoid side effects of drugs.