There are many causes of toothache, such as pulpitis, pericoronitis of wisdom teeth, periodontal swelling and pain, all of which can cause toothache. But all of these causes are basically due to inflammation, so the infusion of anti-inflammatory drugs can relieve toothache. Which dental anti-inflammatory medication is good to use? If you are not allergic to penicillin or cephalosporin, infusion of both penicillin and cephalosporin is fine, as long as one is infused. Patients with more severe symptoms can also add metronidazole, metronidazole plus cephalosporin or metronidazole plus penicillin. For patients who are allergic to penicillin and cephalosporin, levofloxacin or clindamycin are generally recommended, as long as the antimicrobial agent has a certain effect on the toothache.