Quadruple therapy for H. pylori has the potential to cause an increase in bilirubin, but most of these recover when the anti-H. pylori medications are stopped.
The quartet of drugs often referred to includes a proton pump inhibitor, two antibiotics, and a drug to protect the gastric mucosa. Commonly used are omeprazole, amoxicillin, clindamycin, and bismuth potassium citrate. A full course of use is usually required, which is 2 weeks.
Since most drugs are metabolized in the liver, such as amoxicillin and clindamycin in the tetrodrugs, and have a certain degree of hepatotoxicity, it is possible to take tetrodrugs to cause damage to the liver function, which can be manifested as an increase in bilirubin, elevated levels of transferase, and so on.
Most patients can recover their liver function after stopping the use of tetrodrugs. If the bilirubin level is still high after stopping the drug, it is recommended to further improve the relevant examination to clarify whether there are other liver diseases, and the drug is recommended to be used under the guidance of a doctor.