Refractory hypertension, also called intractable hypertension, is defined as a condition in which blood pressure does not reach the standard after taking three or more antihypertensive drugs, including diuretics, on top of improving lifestyle. Causes of refractory hypertension: 1. Poor compliance of patients, such as not taking medication on time. 2. The application of antihypertensive drugs at the same time, taking other drugs that can raise blood pressure, the effect on the effect of antihypertensive, such as hormones, licorice drugs. 3. Not improve the bad habits, such as high salt diet, tired and stay up late, mental stress, which will also make the blood pressure does not come down easily. 4. Suffering from sleep apnea syndrome. 5. other, secondary factors that cause blood pressure to rise. For patients with refractory hypertension, a serum ionization test can be performed to clarify whether the patient has low blood potassium or hypertension? This will help to assess whether the patient has a high-salt diet and whether there are signs of primary aldosteronism. Further, renal vascular ultrasound and adrenal CT can be performed to further rule out whether the patient’s blood pressure is persistently elevated due to renal vascular stenosis or adrenal occupancy. It is also necessary to check renal function and blood glucose. Relatively speaking, patients with renal failure or poor blood glucose control often have difficulty in achieving the blood pressure standard. If the above factors are excluded, you can further check the cranial CT or cranial MRI. Patients with head displacements may also have persistent elevated blood pressure. In addition to identifying the causes, it is important to ask the patient where he or she purchased the antihypertensive medication. Sometimes the patient may have purchased the antihypertensive medication at an unofficial location, and there is a possibility that the medication may be counterfeit, or that the blood pressure may not reach the standard despite taking multiple antihypertensive medications in combination. Clinically common intractable hypertension is often due to renal insufficiency caused by renal hypertension, for other problems caused by intractable hypertension, relatively easy to correct, patients must relax, sometimes the more nervous, the more likely the blood pressure is intractable rise.