Insomnia caused by autonomic nerve disorder can usually be improved in a few months to about 1 year, but it is usually difficult to cure, and the exact time of improvement varies from person to person. 1. The symptoms of autonomic nervous disorder and insomnia caused by acute factors such as work pressure and lack of rest will improve within 3 to 6 months after sufficient rest, professional psychological counseling and treatment with Glutathione and Vitamin B6. 2. The treatment cycle of autonomic nervous disorder and insomnia caused by chronic factors such as personality factors will be longer, and patients need to regulate their own emotions, standardize their daily life and routine, and take antidepressant medicines such as melittrexin and olanzapine regularly to relieve the symptoms of insomnia, which may last for about 1 year or even longer. It is recommended that patients with autonomic disorders and insomnia accept psychological counseling while taking medication and standardizing their daily routine, taking a comprehensive approach to treating insomnia symptoms.