Metronidazole should not be taken until at least 72 hours after drinking to prevent life-threatening disulfiram-like reactions such as nausea and chest tightness. The genus Metronidazole has a strong anti-anaerobic effect. Usually, at least 72 hours interval after alcohol can take metronidazole, mainly because metronidazole and alcohol contact easily cause disulfiram-like reaction, nausea, chest tightness, panic, blood pressure abnormalities, headache, dizziness, dyspnea and other symptoms, and in severe cases, even a sense of imminent death, followed by life-threatening. Therefore, clinicians recommend taking metronidazole three days before without a history of alcohol consumption, and at least seven days after the drug is prohibited from drinking alcohol or eating food containing alcohol. In addition, drinking alcohol while taking the drug will also reduce the therapeutic effect of the drug to a certain extent, which is not conducive to the improvement of the disease. To summarize, patients must strictly take metronidazole under the guidance of the doctor, do not drink alcohol, if there is obvious discomfort after using the drug, you need to go to the hospital in time.