Sweat spot is a disease caused by Malassezia infection. This pathogen is lipophilic and prefers oil-rich areas and gradually engulfs keratin in the skin, resulting in gradually expanding hypopigmented spots. Although progressing slowly, Malassezia is difficult to heal on its own because of its resistance to adverse external conditions. Once detected, active treatment is recommended. Delaying the disease is generally not harmful, but may increase the difficulty of treatment. The main treatment methods include: first, topical selenium disulfide lotion or ketoconazole lotion bath. Second, topical salicylic acid ointment or boutinafine ointment. Third, if the effect is not good, it is recommended to repeat the treatment once after a week interval. Fourth, life attention to more exposure to disinfection clothing.