A 4.0 cm x 4.1 cm hypoechoic mass in the liver is considered to be a possible hepatic hemangioma, hepatic cyst, hepatic malignant tumor, etc. Normal alpha-fetoprotein cannot completely exclude hepatic malignant tumor. 1. Liver hemangioma: liver hemangioma is a kind of congenital developmental abnormality, manifested as a benign tumor formed by a combination of arterial and venous intricacies, most of the patients don’t have obvious clinical symptoms, and surgical resection can be considered for those with huge volume. 2. Liver cysts: Liver cysts are a benign disease, pay attention to regular ultrasound to review the growth rate and size of liver cysts. 3. Malignant tumor of liver: under normal circumstances, the normal value of alpha-fetoprotein is less than 20 micrograms per liter, the patient’s alpha-fetoprotein value is normal, but malignant tumor can not be completely ruled out, and need to be combined with the patient’s clinical symptoms, CT examination, liver puncture pathology and other diagnostic. If you find hyperechoic masses in the liver, you should consult the Hepatobiliary Surgery Department of regular hospitals for a prompt and clear diagnosis.