After antiviral treatment for hepatitis B, elevated transaminases are also a possible phenomenon. If antiviral treatment has just started, the elevation of transaminases may be a temporary situation that the replication of the virus has not been suppressed yet. If the transaminases are elevated at this time, liver-protecting and enzyme-lowering drugs can be applied orally or intravenously to control the inflammation of the liver. If the aminotransferase suddenly rises after a long period of oral antiviral medication, it is important to consider whether it is related to the reactivation of the hepatitis B virus. It is possible to develop resistance to antiviral nucleoside analogues, which can be seen in the DNA quantification of hepatitis B virus, or to stop taking oral antiviral medication in the middle of a period of time, which may also lead to the re-replication of hepatitis B virus, resulting in liver inflammation and elevated transaminases.