The possible causes of l4-5, l5-s1 disc degenerative herniation include long-term strain injury, lumbar degenerative disease, etc. If there is no obvious discomfort, it can be left untreated for the time being, and if there is a combination of discomforts, it can generally be treated with medication, traction, surgery, and so on. 1. Anti-inflammatory and analgesic drugs: l4-5, l5-s1 disc degenerative herniation refers to lumbar 4~5, lumbar 5 sacral 1 disc degenerative herniation. Severe pain can be relieved by anti-inflammatory and analgesic drugs, such as celecoxib capsules, ibuprofen, etc., which may have side effects such as gastrointestinal discomfort. 2. Physical therapy: For the physical therapy of herniated disc degeneration, common methods include massage, massage, traction, lumbar back muscle training, etc. Avoid sitting and standing for a long time, through these methods, the symptoms of pain can be better improved. 3. Surgery: If conservative treatment fails to alleviate the symptoms of pain and mobility impairment, or if severe nerve compression symptoms occur, surgical treatment can be considered, including conventional surgery and minimally invasive surgery, etc., to remove the protruding part and relieve the compression. When l4-5, l5-s1 disc degeneration and herniation occurs, it is recommended to go to the regular hospital in time for consultation and active treatment, do not blindly use drugs.