High creatine kinase may be caused by strenuous exercise, labor in pregnant women, and myocardial ischemia. Patients need to do ECG, cardiac ultrasound and other tests. 1. Strenuous exercise: such as running, long time fitness and other reasons, there can be excessive muscle fatigue caused by anaerobic metabolism resulting in the accumulation of acidic substances. Since high creatine kinase is often found in the muscles, elevated creatine kinase can occur and will be slowly relieved after resting without intervention. 2. Childbirth: Childbirth requires a lot of physical strength and energy from the woman, which tends to aggravate the burden on the heart and cause the heart muscle to have a stress reaction, leading to an increase in the amount of creatine kinase and the appearance of high creatine kinase. The symptoms of heart disease and myocardial infarction can be excluded through the examination of electrocardiogram and cardiac ultrasound. 3. Myocardial ischemia: Myocardial ischemia for a long time causes necrosis of myocardial muscle, which leads to the inability of creatine kinase to metabolize normally, so it will be high. Diseases can also be ruled out by ECG and cardiac ultrasound. In addition, it is recommended to go to the hospital in time for high creatine kinase and follow the doctor’s instructions for treatment to avoid delaying the condition.