Under normal circumstances, it is generally recommended to administer benzylpenicillin after 7 days of alcohol consumption; however, it should be decided in the light of the patient’s own condition as well as the consumption of alcohol and the resulting reaction, so the time cannot be standardized, as follows. Generally it will be recommended that benzylpenicillin can be administered after an interval of 7 days after drinking alcohol; because after 7 days, alcohol has basically been excreted out of the body, and administering penicillin under such circumstances can significantly reduce the adverse reactions. However, if the patient has symptoms such as intoxication, body weakness, dizziness, nausea, vomiting, etc. after drinking alcohol, the time of administering penicillin should be postponed until the body recovers to normal and the alcohol is completely metabolized out of the body. If penicillin is injected when the alcohol has not been completely metabolized out of the body, the possibility of a disulfiram-like reaction cannot be ruled out. Before the injection of benzylpenicillin should be aware of the fact that if you are allergic to the components of the drug, or breastfeeding is contraindicated in childhood; use with caution in the presence of asthma and eczema. Long-term use of the drug may appear rash, itchy skin, etc., usually after stopping the drug will be relieved on its own, without special treatment. If you need to take benzylpenicillin, it should be done under the guidance of a professional physician, and you need to inform the doctor that you have been drinking alcohol before taking the injection, and you can’t drink alcohol within 7 days after taking benzylpenicillin.