In acute pancreatitis, the overflow of pancreatic fluid contains a large number of pancreatic enzymes along the tissue gap diffusion, seepage to the subcutaneous can dissolve subcutaneous fat, so that the capillary rupture bleeding in the skin around the umbilicus appeared cyanotic purple is called Cullen’s sign. In addition to the periumbilical and lateral abdominal wall skin purple spots, there can also be extremity skin damage, purple spots, blisters, necrosis, skin damage is one of the signs of critical condition. The abdominal wall manifestation of acute pancreatitis is part of the systemic disease, and in the clinic, you can see the abdominal wall edema, pressure pain, skin color change and other signs and symptoms. Most of the acute pancreatitis is sudden onset, manifested as severe epigastric pain, and mostly radiating to the back of the shoulders, the patient consciously feel a girdle sensation in the epigastrium and lower back. The location of the abdominal pain is related to the location of the lesion, such as the head of the pancreas lesion is heavy, abdominal pain to the right epigastrium, and radiate to the right shoulder; lesions in the tail of the pancreas, abdominal pain to the left epigastrium is heavy, and radiate to the left shoulder. The intensity of pain is consistent with the degree of the lesion. If edematous pancreatitis, abdominal pain is mostly persistent with paroxysmal aggravation, the use of acupuncture or injection of antispasmodic drugs can make the abdominal pain relief; if hemorrhagic pancreatitis, abdominal pain is very intense, often accompanied by shock, the use of general pain management methods is difficult to stop the pain. How to effectively prevent the skin around the umbilicus from appearing blue and purple? 1, close observation of vital signs, such as blood pressure, pulse, respiration and so on. 2.Strengthen the care of abdominal drainage and biliary, gastric and jejunostomy tubes, keep the drainage smooth, and pay attention to the trait of drainage fluid and the record of drainage flow. 3, abdominal lavage treatment, should be strictly in accordance with the aseptic technical operation and according to the requirements of the doctor’s orders, and accurately record the amount of drops into the lavage fluid, the amount of abdominal suction and its properties, according to the requirements of the doctor’s orders to leave a specimen for amylase and other checks. Actively prevent the various causes of this disease, such as various infectious diseases, such as biliary roundworm, viral infections, sepsis, mycoplasma pneumonia and other diseases; prevention and treatment of metabolic disorders, such as hypercalcemia, hyperlipidemia, diabetes mellitus, etc.; preventing overfeeding and malnutrition; preventing and treating alcoholism and trauma.