Leakage of urine at the age of fifty can be treated with behavioral therapy, physical therapy, medication and surgery under the guidance of a doctor. 1. Behavioral therapy: for example, contracting the anus 200 to 300 times a day is a simple and easy treatment. Patients can also do sit-ups, squatting and other exercises to help exercise the pelvic floor muscles and improve the control of the urethral sphincter. 2. Physical therapy: Place pressure receptors in the female urethra and vagina to transmit the pressure generated by the contraction of the pelvic floor muscles, and instruct the patient to carry out correct anal contraction training. Electrodes can also be placed in the vagina to passively contract the pelvic floor muscles through electrical stimulation, exercising the pelvic floor muscles to enhance urinary control. 3. Medication: Duloxetine, Mirabellone and other medications can be used under the guidance of the doctor, which can reduce the involuntary contraction of the bladder sphincter, reduce the bladder’s contraction force, reduce the pressure on the urethra at the same time, but also increase urethral tension, thus reducing the symptoms of urinary leakage. 4. Surgical treatment: Surgical treatment can be considered according to the patient’s condition and willingness to improve urine leakage, such as transvaginal tension-free sling, mid-urethral suspension, bladder neck filler injection, and anterior vaginal wall folding. By changing the angle of the urethra, thus increasing urethral resistance and controlling urinary incontinence, the clinical application is more obvious. Fifty years old leakage of urine if it affects the work life, should seek medical treatment as early as possible, and follow the doctor’s instructions for systematic treatment.