It is normal for the foramen ovale to remain open in newborns. In most cases, the foramen ovale begins to close two months after birth and closes completely around the age of one week. The foramen ovale is mainly used for blood exchange during the fetal period, and will close after birth with the establishment of pulmonary circulation. Clinically, closure usually begins at two months of age, and complete closure occurs at about one year of age. If the foramen ovale does not close by the age of three, the condition is classified as patent foramen ovale and requires further treatment. Clinical management of foramen ovale agenesis requires a combination of clinical symptoms. Mild cases can be monitored regularly, while obvious symptoms can be repaired mainly by surgery. If the foramen ovale is found to be unclosed at an early stage, do not worry too much, as a large portion of the foramen ovale can close on its own. Once the foramen ovale appears, the scope of unclosure is relatively large, and there are cardiopulmonary function abnormalities need to consult a doctor in time, under the guidance of the clinician to carry out standardized treatment, to avoid delaying the condition.