Pleural thickening is an increase in pleural thickness caused by fibrin deposition and proliferation of granulation weave on top of pleural lesions leading to fibrosis. Usually, patients with pleural thickening will always be present without surgery. If there is mild pleural thickening or localized pleural thickening that does not affect lung function, no special treatment is needed; if there is mild chest tightness, physical exercise such as chest expansion and deep breathing should be strengthened, which can gradually compensate and make the symptoms of chest tightness reduce or disappear; if there is extensive pleural thickening that seriously affects respiratory function or combined with pleural adhesions, surgical treatment, such as pleurodesis, which strips the wall pleura and dirty pleura, should be performed to facilitate lung resorption. The treatment should be carried out to facilitate the reopening of the lung and restore the lung function. At the same time, the primary cause of pleural thickening should be searched for and treated for, and the common causes are infectious, tuberculosis, tumor factors, autoimmune and systemic factors. In conclusion, pleural thickening is irreversible, but in many cases it has no effect on the normal physiological activities of the patient and there is no need to worry about it.