Intracranial infections are one of the very serious diseases of the central nervous system and are frequently encountered and faced in neurosurgical clinical work. If intracranial infections are not treated and disposed of in a timely manner, the consequences are very terrible, with high rates of disability and death. The common pathogens of intracranial infections are mostly gram-positive cocci, but in recent years, with the application of many kinds of high-level antibiotics and the “clinical abuse” caused by the fear of intracranial infections, intracranial infections, which were originally quite treatable, have developed into drug-resistant bacteria that are difficult to cure, or even incurable at a later stage, and some of them will be infected with “super-resistant bacteria”. Some people may be infected with “super-resistant bacteria” or fully drug-resistant bacteria, for which common antibiotics are ineffective, which is a very scary thing in the clinic. Some patients ask how long it usually takes to heal from an intracranial infection. Intracranial infections don’t usually heal on their own if left untreated. And the treatment of intracranial infections generally takes a relatively long period of time, and many patients in the clinic may require months of treatment. Because of the existence of the blood-brain barrier, which is a protective mechanism for brain tissue, but it also makes the general antibiotics can not reach the brain, so the treatment of intracranial infections has always been a thorny problem in neurosurgery. The treatment of intracranial infections requires a timely, correct, comprehensive and scientific diagnosis and treatment plan, which firstly requires the specialty of cerebrospinal fluid department to overcome the obstacle of blood-brain barrier and carry out antimicrobial treatment for intracranial infections, and secondly, requires the normalization of cerebrospinal fluid volume, cerebrospinal fluid composition, and abnormalities of cerebral ventricular wall, etc, so as to comprehensively restore cerebral and neural functions.