The generic name of Tonicare is Estradiol Valerate Tablets. Bleeding on taking estradiol valerate tablets and progesterone for 12 days may be normal or may be related to a missed dose. Bleeding on taking Estradiol Valerate Tablets and Progesterone for 12 days is considered to be caused by changes in sex hormones. When taking estradiol valerate tablets and progesterone, it will lead to changes in sex hormones, which will cause patients to experience a small amount of vaginal bleeding, which is usually normal. Bleeding after 12 days of taking estradiol valerate tablets and progesterone, if it is a symptom of a small amount of vaginal bleeding, it is recommended to continue to take the medication first, a small amount of bleeding is related to the leakage of the medication, then continue to take the medication and observe it. If the bleeding is heavy, try to stop taking the medication. Estradiol valerate tablets and progesterone should be used under the guidance of a doctor, do not blindly take on their own; if persistent bleeding or heavy bleeding should be timely consultation to identify the cause.