Chinese medicine can treat cholangiocarcinoma, but it can only be used as auxiliary supplementary treatment, not as the main treatment. Cholangiocarcinoma is a kind of malignant tumor occurring in bile duct system, the cause of which is still unknown, and it may be related to hepatic and bile duct stones, liver and bile duct infection and so on. The main symptoms can be seen as abdominal discomfort, epigastric mass, jaundice and so on. Clinical treatments for cholangiocarcinoma include general treatment, surgery, chemotherapy, radiotherapy, etc. Surgery is the preferred treatment. In Chinese medicine, bile duct cancer can belong to the categories of “jaundice”, “abdominal pain”, “bulging”, etc. It is mostly caused by internal injuries of emotions and feelings, which lead to liver depression and stagnation of qi, negligence of liver and gallbladder excretion, and preference for fat and greasy food, which lead to internalized dampness and heat, and fumigation of biliary tract. The bile duct is fumigated, the liver is depressed and the spleen is deficient and unable to push the evil out, and the bile duct is stagnated and triggered. The main treatment principle is to clear away heat and eliminate dampness, tonify the qi and strengthen the spleen, and the specific prescription is chosen according to the clinical diagnosis and typing. All in all, it is not recommended to take Chinese medicine as the main treatment program. If cholangiocarcinoma is suspected or diagnosed, one should go to regular hospitals for consultation and treatment in a timely manner, follow the doctor’s instructions to actively cooperate with the treatment, and choose the appropriate treatment plan in order to avoid delaying the condition. For medication, please strictly follow the doctor’s prescription and do not use medication on your own.