Low G-6-PD in newborns may suggest serosanguineous disease, an acute hemolytic disease, in which case genetic diagnosis, routine blood, urine, liver and kidney function tests, abdominal ultrasound should be performed to rule out or make a definitive diagnosis, and close observation should be performed. Serrapeptosis is also known as glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, and when it leads to acute hemolysis of the organism, it will manifest symptoms such as fever, jaundice, soy sauce-colored urine, nausea and vomiting, and abdominal pain. Therefore, newborns with low G-6-PD need to undergo relevant tests to determine whether there is a possibility of fava bean disease. Genetic diagnosis can clearly diagnose fava bean disease, and thus speculate on its severity, clinical manifestations, etc.; routine blood tests can determine whether there is anemia, early hemolysis, etc., to assist in the diagnosis. Urinalysis can determine whether there is hemolysis based on the presence of blood in the urine; liver and kidney function tests may clarify the severity of jaundice; and abdominal ultrasound may determine whether there is hepatosplenomegaly, etc. If a diagnosis of serosanguineous disease is made, the patient may be diagnosed with serosanguineous disease. If the diagnosis is fava bean disease, appropriate treatment is needed according to the condition; if the diagnosis of fava bean disease is excluded, changes in G-6-PD and the condition of the newborn baby need to be closely monitored, and timely treatment is needed if abnormalities occur.