Cranial repair is not only a protective layer for the soft tissues of the brain, but also an important guarantee for maintaining the aesthetics of the head. It is important to perform cranial repair as early as possible when the skull is defective. How to choose the material for skull repair? Material is the most important thing for skull repair surgery. A good material can not only improve the success rate of the surgery. And it can reduce the chance of post-operative complications. There are titanium mesh and peek material for skull repair, what is the difference between these two? With the advancement of medicine, more and more cranial repair materials have gradually become available for use. Plexiglass, light apatite and calcium phosphate cement materials, which were once used clinically, are gradually being withdrawn from the medical scene due to their poor clinical results. The commonly used material for cranial repair today is titanium mesh, which is also a quality material with long-lasting application and good results. However, the metallic properties of titanium mesh often have consequences for patients such as sensitivity to cold and heat reactions and CT image errors. Thanks to the efforts of medical researchers, a new type of cranial repair material has been applied above the clinical level, and that is PEEK material. The material is known as polyether ether ketone, a polymer biomaterial that is extremely close to human cranial bone in terms of elasticity, heat transfer, hardness, and stability, etc. The use of three-dimensional shaping of the PEEK bone plate can be completely compatible with the cranial structure, without worrying about precision and aesthetics. Numerous clinical cases have shown that there are no discomfort or complications associated with PEEK cranial bone repair materials, so PEEK is currently the better choice for cranial bone repair. Therefore, cranial repair surgery should be performed promptly after a cranial defect. Of course, the material used for cranial repair is important. The application of cranial repair materials has changed with the age. Plexiglass and bone cement have been eliminated in the cranial defect surgery. Nowadays, titanium mesh and polymer polyether ether ketone are the two main types of cranial repair materials used in cranial defects, which are the mainstream cranial repair materials. So what is the difference between these two materials? The advantages of polyetheretherketone: First, elasticity, hardness, thermal conductivity is similar to cranial bone; Second, good histocompatibility; Third, there is no micro-shadowing on X-ray and nuclear magnetic, which does not affect doing nuclear magnetic and CT. but its disadvantage is that the price is relatively slightly expensive. The advantage of titanium alloy is relatively cheap, but the disadvantages are: a) chronic rejection; b) thermal conductivity; c) micro-shadowing after MRI, which affects detailed observation.