Ibuprofen can generally be taken with methylcobalamin, but should be taken under a doctor’s supervision. Ibuprofen is a non-steroidal anti-inflammatory drug. It has analgesic, anti-inflammatory and antipyretic effects. Methylcobalamin is an endogenous coenzyme B12, which is mainly used in the treatment of megaloblastic anemia and peripheral neuropathies, and can generally play a role in nourishing the nerves. There is no clinical data to indicate that these two drugs together will cause adverse reactions, patients should be under the guidance of the doctor reasonable use of medication. Ibuprofen is used to relieve pain, such as headache, migraine, toothache, menstrual cramps, etc. It is also suitable for fever caused by common cold or influenza. Some patients may experience adverse reactions such as vomiting, nausea and abdominal pain after taking the drug. This drug is contraindicated in people who are allergic to NSAIDs, pregnant and lactating women, and patients with severe liver disease, kidney disease, and hypertension. Methylcobalamin is an endogenous coenzyme B12, which is involved in the one-carbon unit cycle and plays an important role in the transmethylation reaction in the synthesis of methionine from homocysteine. It is usually used in the treatment of megaloblastic anemia as well as peripheral neuropathies and other diseases, and can play a role in nourishing the nerves. Some patients may experience gastrointestinal adverse reactions, such as loss of appetite, nausea, vomiting, diarrhea, etc.; allergies, such as skin rashes, etc., after using the drug. The drug is contraindicated in patients with a history of hypersensitivity to methylcobalamin or any of the excipients in the prescription. Its safety in pregnant and breastfeeding women is not known. If you need to use ibuprofen and methylcobalamin, it is recommended that you consult a medical professional and use the medication as prescribed.