Patients stay up late with itchy eyes, mostly caused by visual fatigue, but also may be related to conjunctivitis, dry eye and other reasons. 1. Visual fatigue: due to long time reading, reading cell phones, staying up late and other excessive eye use, can lead to long time in the eyes in congestion, the patient may appear conjunctival congestion, itchy eyes, dryness, tearing and other uncomfortable symptoms. 2. Conjunctivitis: powder, dust, bacteria and other foreign objects into the eyes, easy to lead to conjunctivitis, in the inflammation stimulation, the patient’s eyes can appear pain, redness, swelling, itching and other symptoms, stay up late to further aggravate the symptoms. 3. Dry eye: dry eye patients due to insufficient tear secretion or evaporation, patients can appear visual fatigue, dryness, foreign body sensation, itchy eyes and other uncomfortable symptoms, part of the patients stay up late after the symptoms can be aggravated. It is recommended that patients with noticeable itchy eyes should consult a doctor in time to assess their condition and receive treatment under the guidance of a professional doctor.