If you suffer from gonorrhea after taking cephalosporin drugs are not effective, you can change the use of macrolide, azithromycin, doxycycline and pay attention to the observation of the efficacy of the treatment, timely adjustment of the treatment program, to prevent the failure of treatment. Gonorrhea is a sexually transmitted disease caused by Neisseria gonorrhoeae, mainly manifested as purulent infection of the genitourinary system. Men are mostly characterized by acute urethritis and women by cervicitis. Commonly used drugs for gonorrhea include ceftriaxone sodium, cefotaxime, macrolide, azithromycin, and so on. If symptoms are not effectively controlled after 20 days of cephalosporin, it is necessary to identify reinfection or treatment failure, and obtain drug susceptibility test data if possible. If the treatment is not effective, the dose can be increased and the treatment can be repeated, or replaced by Spectinomycin, Azithromycin, Doxycycline, the specific use of medication should be in accordance with the doctor’s instructions. It is recommended to be clean, not promiscuous, have reasonable rest, and do appropriate physical exercise to enhance resistance and promote recovery.