Post-freezing blisters are small and generally not recommended to be picked. If the blisters are large, you can extract the blister fluid under the guidance of the doctor, and then anti-infection treatment. Freezing refers to liquid nitrogen freezing, which is a common clinical treatment that can be used for all kinds of warts and superfluous organisms. Liquid nitrogen freezing is the use of refrigerant generated by the low temperature, so that the lesion tissue necrosis, can achieve the purpose of treatment. Blisters that appear after freezing may be a reaction to freezing. Freezing causes small blisters to appear on the skin, which usually do not require special treatment. Over time, the blisters may naturally dry up, crust over, and fall off. For larger blisters formed by freezing, it is recommended to take good care of the affected area by sterilizing the blister and surrounding skin with iodine vapour, and withdrawing the blister with a sterile syringe to keep the wall of the blister intact. After that, apply erythromycin ointment and fusidic acid cream externally to prevent infection. In summary, localized blisters after freezing are not recommended to be treated by oneself to avoid infection. If the blisters are large or accidentally broken, it is recommended to consult a doctor in time and deal with them under the doctor’s guidance.