The first thing to do after six years of kidney transplantation with cold and fever is to lower the temperature, then clarify the cause of the disease and treat the symptoms (oral amoxicillin, antiviral granules, etc.). First of all, it is necessary to lower the temperature, when the body temperature is too high, it may cause irreversible damage to the organism brain, heart and other organs, in order to avoid the occurrence of the above mentioned situation, lowering the temperature treatment is very critical, if the body temperature is not more than 38.5 degrees Celsius, you can take the physical cooling methods, such as alcohol wipes, if the body temperature is higher, it is necessary to take oral medication (such as ibuprofen and so on) to lower the temperature treatment. Secondly, it is necessary to clarify the cause of the disease. Cold is a kind of upper respiratory tract infection, which is usually caused by pathogen infection. You can follow the doctor’s instructions to improve the blood cell analysis, C-reactive protein, procalcitonin, respiratory virus test, lung CT, blood culture and other indexes, so as to clarify the cause of the disease, and then carry out the anti-infective or anti-viral treatment under the guidance of the physician, such as oral amoxicillin, anti-viral granules and so on. Patients with fever after renal transplantation need to consult regular hospitals in time to identify the cause and standardize the treatment under the guidance of physicians.