The specific treatment for a large difference in vision between two eyes is related to the cause of the patient’s poor vision. Patients with myopia can have their vision corrected by wearing eyeglasses or myopia surgery, patients with amblyopia can have their amblyopia treated by masking therapy, and patients with keratoconjunctivitis can have their vision improved by treatment such as medication or surgery. Due to the large difference in vision between two eyes caused by myopia, astigmatism and other refractive errors, minors can consider wearing glasses to correct their vision, such as wearing framed glasses or corneal contact type of glasses. Adults can consider wearing glasses or undergoing myopia surgery to correct their vision. Surgical procedures include corneal refractive surgery and lens implantation. If the difference in vision between the two eyes is large due to amblyopia, it is necessary to wear glasses to correct the refractive error, cover the emmetropic eye for treatment, and stimulate the visual development of the amblyopic eye. If the difference in vision between two eyes is caused by localized lesions, such as monocular cataract, keratitis and other lesions, patients need to be actively treated by drugs or surgery, such as tobramycin eye drops, cataract ultrasonography combined with IOL implantation and so on. It is recommended that patients with vision loss should consult the hospital in time to assess their condition and follow the doctor’s instructions for treatment.