People who do not have contraindications to calcium hydroxybenzenesulfonate and metformin can be combined with these two drugs, but please under the guidance of a doctor. Calcium hydroxybenzenesulfonate can be used for the treatment of microvascular lesions, such as diabetic retinopathy, can also be used for the treatment of varicose veins, should not be used for allergy to this drug and pregnant women, lactating women; Metformin can be used for the treatment of type 2 diabetes mellitus patients who can not control their blood glucose well with diet and exercise alone, and should not be used for the people who are allergic to this drug and suffer from heart failure. If there is no contraindication to the above two drugs, patients can be combined with calcium hydroxybenzenesulfonate and metformin treatment. However, it should be noted that metformin may cause nausea, abdominal pain, diarrhea, vomiting and other adverse reactions; the use of calcium hydroxybenzenesulfonate treatment may cause stomach upset, nausea, lack of appetite and other adverse reactions. Patients who need to combine calcium hydroxybenzenesulfonate and metformin treatment should use it under the guidance of a doctor.