Liver injury and diffuse hepatic changes are both more serious and it is impossible to distinguish the difference in severity. Liver injury is mostly acute and requires urgent treatment, while diffuse liver changes are mostly caused by liver cirrhosis, liver fibrosis and even liver cancer, which need to be taken seriously. 1. Liver injury is mostly acute, divided into four types: pathological liver injury, drug liver injury, open injury and closed injury, which can lead to liver failure and hemorrhagic shock and other risks, so it is more serious. 2. Diffuse hepatic changes belong to chronic lesions, which are usually caused by cirrhosis, metabolic dysfunction, stasis disease, parasites and so on. Diffuse hepatic changes lead to changes in the normal structure of the liver, which leads to the emergence of hepatic fibrosis and ultimately the risk of cancerous lesions and liver failure. Patients with symptoms of acute or persistent liver injury or diffuse hepatic changes should seek medical attention as soon as possible, undergo active treatment, and undergo regular follow-up.