The answer to the question of whether or not a transplant is needed for AML after three rounds of chemotherapy is not generalizable, but needs to take into account the type of leukemia and the individual’s specific situation. Acute myeloid leukemia with three chemotherapy treatments and all the indicators are normal, which means that the disease has been significantly relieved after chemotherapy, but we cannot rule out the possibility of relapse, and after relapse, bone marrow transplantation may still be needed. Acute myeloid leukemia generally requires bone marrow transplantation for cure, but some types of AML can be cured without bone marrow transplantation, such as M3 AML, which can be treated with medication. Therefore, the need for a bone marrow transplant should be decided by a professional doctor after a comprehensive assessment. It is recommended to ask the doctor’s opinion and consider a bone marrow transplant if the condition requires it.