Elderly people with large differential pressure may be due to hypertension, hyperthyroidism, rheumatic heart disease and other conditions, patients need to take hydrochlorothiazide, propranolol and other drugs as prescribed by the doctor. 1. Hypertension: Usually patients need to follow the doctor’s instructions to use hydrochlorothiazide, furosemide and other diuretics, but also nifedipine, amlodipine and other calcium channel blockers, some patients can also use propranolol, metoprolol and other β-blockers or captopril, enalapril and other angiotensin-converting enzyme inhibitors treatment. 2. Hyperthyroidism: Usually, patients need to be treated with antithyroid drugs such as prothiothiophene and imidazole with beta-blockers such as propranolol. In case of severe thyrotoxic heart disease or thyroid crisis, iodine can be used, and the drug can also be used for preoperative preparation. 3. Rheumatic heart disease: usually patients need to follow the doctor’s instructions to use penicillin, erythromycin, lincomycin and other antibiotic drugs, and also need to use warfarin, aspirin and other anticoagulants. If the patient has cardiac insufficiency, it is also necessary to use spironolactone, furosemide and other diuretics. It is recommended that patients with large blood pressure differentials find out the cause of the disease under the guidance of a doctor and actively carry out targeted treatment.