Pimples that feel bulbous but can’t be squeezed out generally refer to localized firm pimples caused by acne or skin boils, and are treated with medication, surgery, and enhanced skin care. 1. Medication: Acne and boils are infectious skin diseases, and anti-infective medications such as oral amoxicillin capsules and doxycycline, topical mupirocin ointment, and fusidic acid cream should be used to treat them. 2. Surgical treatment: for abscesses that have formed, but have not broken through the infected lesions, it is necessary to carry out timely incision and drainage of pus treatment. 3. Strengthen skin care: keep the local skin clean, avoid too much stimulation and extrusion, so as not to aggravate the infection, pay attention to light diet, avoid staying up late. Pimples feel bulging but can not be squeezed out of the situation should pay attention to avoid extrusion, due to the therapeutic effect will have a certain difference, the specific use of medication need to ask the doctor for an interview, follow the doctor’s instructions standardized treatment, do not self-medication.