Rh-negative blood pregnancies with an ectopic pregnancy in the first pregnancy and a second pregnancy is one that may or may not be hemolyzed. Women with Rh-negative blood may not experience hemolysis in the second pregnancy if the first child is Rh-negative. If the first child is Rh-positive, even though it was an ectopic pregnancy, it can cause the mother to develop antibodies to the Rh blood group, and hemolysis can occur if the second child is Rh-negative. For women with Rh-negative blood, it is necessary to determine the blood type of the fetus during pregnancy. If the fetus is Rh-positive, the fetus needs to be monitored regularly for elevated antibodies and checked for signs of edema, fluid retention, and anemia. If necessary, plasmapheresis, intrauterine transfusion and postpartum blood exchange can be used to treat severe anemia. It is recommended to consult a doctor in time for standardized diagnosis and treatment.