Bleeding duodenal ulcer may be caused by improper diet, drugs, Helicobacter pylori infection, and psycho-psychological factors. It is necessary to choose drug treatment or surgery according to the cause and the amount of bleeding. Common causes 1, improper diet: drinking alcohol, eating spicy and irritating or too hard food, resulting in the rupture of capillaries in the stomach wall, can cause bleeding duodenal ulcers; 2, drugs: long-term use of non-steroidal anti-inflammatory drugs such as aspirin, and glucocorticoids, etc., can lead to duodenal ulcers, ulcer site rupture and bleeding in severe cases; 3, Helicobacter pylori infection: Helicobacter pylori infection leads to duodenal mucosa sites ulcerative lesions, if the ulcer is larger or deeper, easy to invade the surrounding blood vessels, resulting in bleeding duodenal ulcers; 4, psychosomatic factors: patients in a high degree of mental tension, stress, may lead to bleeding duodenal ulcers. Treatment Patients need to fast, stop using drugs that cause bleeding duodenal ulcer, and continue to use or switch to other drugs after ulcer bleeding improves, while adding gastric mucosal protective agents. When the bleeding is not large, acid suppressants, hemostatic and gastric mucosa-protective drugs can be used under the guidance of the doctor to control the development of the disease, commonly used drugs such as omeprazole and aluminum thioglycollate. In case of bleeding duodenal ulcer caused by H. pylori infection, quadruple therapy, i.e. 1 proton pump preparation + 2 antibiotics + 1 bismuth agent, can be used after the bleeding stops. In case of heavy bleeding, endoscopic hemostatic treatment is required. Attention is also paid to intravenous rehydration, and blood transfusion is required if necessary.